KMID : 0364020070400110759
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Korean Journal of Thoracic and Cardiovascular Surgery 2007 Volume.40 No. 11 p.759 ~ p.764
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The Effect of Thymoma on Remission for Patients Who Undergo Thymectomy for Myasthenia Gravis
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Kim Hee-Jung
Kim Dong-Kwan Park Seung-Il Kang Sung-Sik Lee Eung-Sirk Kim Yong-Hee Bae Chi-Hoon
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Abstract
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Background: Thymoma occurs in approximately 10% of myasthnia gravis patients. The thymus or a thymoma plays a role in the pathogenesis of myasthenia gravis. However, there is currently no definitive position about the effect of thymectomy on patients¡¯ symptoms and prognosis. We retrospectively studied the effect of thymoma on remission in patients who underwent thymectomy for myasthenia gravis.
Material and Method: From July, 1992 to December, 2002, we performed extended thymectomy due to myasthenia gravis for 100 patients. The thymoma group included 30 people, the non-thymoma group included 70 people and the change of the Ossermann stage between the two groups after surgery was compared.
Result: For the non-thymoma group, the average age was 34.7 years (range: 12.7¡47.7). Before the surgical operation, the Ossermann stage for the non-thymoma group was an average of 3.06, and this was reduced to an average of 1.41 after operation. For the thymoma group, the average age was 50.9 years (range: 37.3¡64.5). Before the surgical operation, the Ossermann stage for the thymoma group was an average of 3.00, and this was reduced to an average of 1.47 after operation. The non-thymoma patients had a higher proportion of males than the thymoma patients (35% vs 30%, respectively). The Masaoka stage was stage of the thymoma group was I for 27 patients and stage II for 3 patients. There was no statistically significant Ossermann stage change between the thymoma and non-thymoma groups.
Conclusion: Whether thymoma was present or not, there was no significant difference on remission and improvement of myasthenia symptoms after thymectomy in the myasthenia gravis patients. (Korean J Thorac Cardiovasc Surg 2007;40:759-764)
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KEYWORD
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Thymoma, Myasthenia gravis, Thymectomy
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